|
KMID : 1123920020160040764
|
|
Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 4 p.764 ~ p.767
|
|
|
Study on the Effect of Flos Carthami on Cultured Osteoblasts Damaged by Methylmercuric Chloride
|
|
Min Bu-Ki
Hong Kee-Yeon
Oh Yeon-Kyun
Shin Yong-Il
Han Sun-Hee
Lee Sang-Bork
Shin Min-Kyo
Jeon Byung-Hoon
Song Ho-Jun
Ryu Do-Gon
Park Seung-Taeck
|
|
|
Abstract
|
|
|
|
To evaluate the osteotoxic effect of methylmercuric chloride(MMC) on cultured mouse osteoblasts, cytotoxic effect was measured by MTT assay after cultured mouse osteoblasts were incubated with various concentrations of MMC for 20 hours. The protective effect of Flos Carthami(FC) against MMC-induced osteotoxicity was also examined in these cultures. MMC decreased cell viability of cultured mouse osteoblasts remarkably in a dose- and time-dependent manners. In protective effect of FC was remarkably effective in blocking the osteotoxicity induced by MMC. From aboved the results, it is suggested that MMC induce osteotoxicity, and the selective herba extract such as FC is very effective in blocking MMC-mediated neurotoxicity on cultured mouse osteoblasts.
|
|
|
KEYWORD
|
|
|
Methylmercuric chloride, Cultured osteoblast, Flos carthami
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|